منابع مشابه
Mast Cell Clonal Disorders: Classification, Diagnosis and Management
Mast cell clonal disorders are characterized by the clonal proliferation of pathological mast cells as a result of somatic mutations in the KIT gene, most commonly the D816V mutation. Accumulation and degranulation of these cells causes a wide variety of symptoms. Mast cell clonal disorders can be divided into mastocytosis and monoclonal mast cell activation syndrome, depending of the level of ...
متن کاملMastocytosis and Mast Cell Disorders
The excess release of mediators can cause clinical features such as pruritus, flushing, nausea, vomiting, diarrhoea, abdominal pain, vascular instability and anaphylaxis. Also, complications may arise when mast cells accumulate in the skin, gastrointestinal tract, bone marrow, liver, spleen, and lymph nodes. [2] The clinical features of systemic mastocytosis are caused by accumulation of clonal...
متن کاملMastocytosis and Mast Cell Disorders
The excess release of mediators can cause clinical features such as pruritus, flushing, nausea, vomiting, diarrhoea, abdominal pain, vascular instability and anaphylaxis. Also, complications may arise when mast cells accumulate in the skin, gastrointestinal tract, bone marrow, liver, spleen, and lymph nodes. [2] The clinical features of systemic mastocytosis are caused by accumulation of clonal...
متن کاملMastocytosis and Mast Cell Disorders
The excess release of mediators can cause clinical features such as pruritus, flushing, nausea, vomiting, diarrhoea, abdominal pain, vascular instability and anaphylaxis. Also, complications may arise when mast cells accumulate in the skin, gastrointestinal tract, bone marrow, liver, spleen, and lymph nodes. [2] The clinical features of systemic mastocytosis are caused by accumulation of clonal...
متن کاملSpectrum of mast cell activation disorders.
Mast cell (MC) activation disorders present with multiple symptoms including flushing, pruritus, hypotension, gastrointestinal complaints, irritability, headaches, concentration/memory loss and neuropsychiatric issues. These disorders are classified as: cutaneous and systemic mastocytosis with a c-kit mutation and clonal MC activation disorder, allergies, urticarias and inflammatory disorders a...
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ژورنال
عنوان ژورنال: The Journal of Molecular Diagnostics
سال: 2006
ISSN: 1525-1578
DOI: 10.2353/jmoldx.2006.060022